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- W2386273670 abstract "In order to evaluate the efficacy and safety of Mizolastine for treatment of chronic idiopathic urticaria, a multicenter randomized comparative study versus Loratadine was carried out from April to October in 2000. 154 subjects completed the trial, including 74 cases in Mizolastine group and 74 cases in Loratadine group. Total 9 subjects withdrew and dropped out from the trial. All symptom scores decreased significantly after treatment ( P 0.05 ) in both group. The score decrease (score before treatment minus score after treatment) of weal in Mizolastine group was significantly greater than that in Loratadine group ( P 0.05). The score decrease of other symptoms did not show statistical difference between two groups ( P 0.05). Efficacy assessment based on symptom score reducing index (SSRI) showed that the efficacy of Mizolastine was 90.1%, and the excellent rate was 52.1%,while the efficacy of Loratadine was 85.1%, and the excellent rate was 45.9%. No serious adverse events were reported in the two groups. The incidences of adverse reaction assessment (ADRs) of Mizolastine and Loratadine were 21.1% and 34%, respectively. The ADRs in Mizolastine group were mild or moderate drowsiness (16.9%) and dry mouth (2.8%),and in Loratadine group were mild or moderate drowsiness (16.2%) and light dry mouth (5.4%). There were no significant changes in blood and urine routine tests, liver and renal functions,and ECGs after treatment in the two groups. No significant change on QTc was found. Conclusion: The efficacy of Mizolastine and Loratadine is similar in the treatment of AR, but the score decrease of stuffy nose with Mizolastine group is significantly more evident than that with Loratadine. The incidences of ADR are not different in the two groups." @default.
- W2386273670 created "2016-06-24" @default.
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- W2386273670 date "2001-01-01" @default.
- W2386273670 modified "2023-09-24" @default.
- W2386273670 title "A multicenter, randomized, comparative study on the safety and efficacy of Mizolastine versus Loratadine for the treatment of chronic idiopathic urticaria" @default.
- W2386273670 hasPublicationYear "2001" @default.
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