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- W2386276551 abstract "Objective The expressions and changes of IL-15 in the early knee post-traumatic osteoarthritis model in rabbits were observed in order to further elucidate the pathomechanism of post-traumatic osteoarthritis.Methods 48 healthy rabbits in total were divided into experimental group and control group randomly with 24 in each group.The anterior,posterior cruciate ligament,medial collateral ligament,and full medial meniscus of the left-posterior knee were cut off for the experimental group,while the control group was subjected to unilateral arthrotomy as pseudo operative controls.The specimens were collected at various time points after the surgery (6,12,24 h and 1,2,3,4 week respectively).the enzyme-linked immunosorbent assay (ELISA) was performed to measure the expression of IL-15.The morphological change of cartilage and synovium were investigated.Results Totally 29 rabbits of the 48 rabbits were involved in the result analysis.The expression of IL-15 at 6 h was significantly higher than those at any other time points(P0.05).Compared with the expression of IL-15 at 24 h,that at 1 week decreased remarkably(P0.05).The expression of IL-15 ascended in proper order of 1,2,3 and 4 week.The expression of IL-15 in experimental group was significantly higher than those in control group(P0.05).4 weeks after operation in experimental group,articular cartilage lost original luminosity,exhibiting gray-yellow color with small crevasse on the surface;HE staining could see the following features:a slightly rough surface layer with small crevasse,hyaline degeneration,fiber tissue hyperplasia,weakened focal cartilage matrix metachromia,decreased number of chondrocyte,and fibrosis of cartilage matrix.Conclusion At the early stage of post-traumatic osteoarthritis,the expression of interleukin-15 is upgraded with cartilage and synovium degenerated,thus,interleukin-15 is closely involved in the early stage of post-traumatic osteoarthritis." @default.
- W2386276551 created "2016-06-24" @default.
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- W2386276551 date "2010-01-01" @default.
- W2386276551 modified "2023-09-23" @default.
- W2386276551 title "Study on the Expression of IL-15 in the Knee of Post-traumatic Osteoarthritis Model in Rabbits" @default.
- W2386276551 hasPublicationYear "2010" @default.
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