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- W2386276688 abstract "Objective To study the changes of peripheral blood fibroblast growth factor-23(FGF-23)level and its significance in the patients with early stage of type 2 diabetic nephropathy(T2DN).Methods 98 outpatients and inpatients with type 2 diabetic mellitus(T2DM)in our hospital from March 2012 to November 2013 were divided into the simple DM group(31cases),early diabetic nephropathy(DN)group(34 cases)and clinical DN group(33 cases).30 healthy individuals were selected as the control group.Peripheral blood FGF-23 level was detected by enzyme-linked immunosorbent assay(ELISA).Serum CysC,P and Ca were measured in the same time.And eGRF was calculated based on height,weight,age,gender and serum creatinine.Results The FGF-23 and CysC levels in each group of T2DM were significantly higher thatn those in the healthy control group and eGFR was significantly lower than that in the healthy control group(P0.05,P0.01).Compared with those in the simple DM group,the FGF-23 and CysC levels in the early DN group were significantly increased and eGFR was significantly decreased(P0.05);the FGF-23 and CysC levels in the clinical DN group were further increased compared with those in early DN group and eGFR was further reduced(P0.01).The serum P level had no statistical differences among the healthy control group,simple DM group and early DN group(P0.05).But serum P level and the product of Ca×P in the clinical DN group were significantly higher than those in the other groups(P0.01).The correlation analysis showed that the FGF-23 level in the DN patients was positively correlated with the CysC and P levels(P0.01)and negatively correlated with eGFR(P0.01),but there were no correlation between FGF-23 with age,BMI and Ca(P0.05).Conclusion The increase of peripheral blood FGF-23 level in early T2DN is earlier than the changes of Ca and P,moreover the FGF-23 level is gradually increased with DN progress.FGF-23 can be used as one of the effective indexes of early T2DN diagnosis and may become as the warning indicator to T2DN progress." @default.
- W2386276688 created "2016-06-24" @default.
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- W2386276688 date "2014-01-01" @default.
- W2386276688 modified "2023-09-26" @default.
- W2386276688 title "Changes of peripheral blood FGF-23 level in patients with early stage of type 2 diabetic nephropathy and its significance" @default.
- W2386276688 hasPublicationYear "2014" @default.
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