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- W2386288584 abstract "Background Experimental research demonstrated that oxidative damage was associated with age-related cataract closely.Curcumin has the effect of anti-inflammatory,anti oxidation,anti tumor and the role of immune suppression.Objective The purpose of this research was to assess the effect of curcumin on sodium selenite-induced cataract.Methods The lenses were obtained from 40 rabbits and cultured in DMEM containing 10% fetal bovine serum and randomly divided into 5 groups:control group,sodium selenite-treated group (30 μmol/L ),30 mg/L curcumin-treated group,50 mg/L curcumin-treated group and catalin-treated group (1%).The transparence of lenses cultured in vitro were observed and graded in the time points of 24,48,72 and 96 hours.At the end of the incubation period,the contents of glutathion peroxidase(GSH-Px),malondialdehyde (MDA) and superoxide dismutase (SOD) in lenses were examined for biochemical parameters by spectrophotometry.Results No obvious difference was found in the numbers of opacity lens between curcumin-treated lenses and control group (P0.05),but significant difference was seen between the curcumin-treated group and sodium selenite-treated group or catalin-treated group in 48 hours and 72 hours after culture(H=10.607,P0.01;H=8.258,P0.05).In the time point of 96 hours,the numbers of opacity lens were considerably decreased in curcumin-treated group compared with control group (u=7.102,P0.05),catalin-treated group and sodium selenite-treated group (H=9.699,P0.05).The content of MDA was evidently increased,and those of GSH-Px and SOD were significantly decreased in sodium selenite-treated group compared with control group (P0.01).The contents of GSH-Px and SOD in lens in curcumin-treated group and catalin group were higher than that of the sodium selenite-treated group and were lower than that of the control group(P0.01).The contents of MDA in lens in different curcumin-treated group and catalin-treated group were lower than that of the sodium selenite-treated group (P0.01)and are higher than that of the control group(P0.05).Conclusion Curcumin has the effect of antioxidation damage to lens and therefore delay cataract.Antioxidation effect of curcumin is more dominant than catalin.However,both curcumin and catalin can not arrest the formation of cataract at the end of the experiment duration." @default.
- W2386288584 created "2016-06-24" @default.
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- W2386288584 date "2010-01-01" @default.
- W2386288584 modified "2023-09-26" @default.
- W2386288584 title "Effects of curcumin on sodium selenite-induced cataract in vitro" @default.
- W2386288584 hasPublicationYear "2010" @default.
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