Matches in SemOpenAlex for { <https://semopenalex.org/work/W2386291279> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2386291279 endingPage "298" @default.
- W2386291279 startingPage "296" @default.
- W2386291279 abstract "Objective To investigate the effects of calcip otriene,tretinoin and triptolide on mRNA expression of vascular endothelial growth factor(VEGF)in primary cultured keratinocytes a nd COLO16 cell line.Methods VEGF mRNA levels were determined by reverse transcriptase polymerase ch ain reaction(RT-PCR).Results Calcipotriene inhibited the mRNA expression of VEGF in a dose-dependent manner in keratinocytes after4hour and 24hour treatment.The 50%i nhibitory concentation values(IC 50)of calcipotriene were 1.19×10-4μg/mL(KC 4h),1.51×10-4μg/mL(KC 24h)and 3.16×10-5μg/mL(COLO1624h)respectively.Tretinoin in-hibited the mRNA expression of VEGF in keratinocytes after 4hours,and had no inhibition in keratinocytes after 24hours and in COLO16 cells after 4hour s and 24hours.Triptolide had no inhibition.Conclusion The antipsoriatic effect of calcipotriene and tretinoin may be partly explained by their in hibition on VEGF production at transcription level.Key words: Endothelial growth factors; Calcipotriene; Tretinoin; Triptolide" @default.
- W2386291279 created "2016-06-24" @default.
- W2386291279 creator A5010729427 @default.
- W2386291279 creator A5021920268 @default.
- W2386291279 creator A5055207211 @default.
- W2386291279 date "2002-08-15" @default.
- W2386291279 modified "2023-09-22" @default.
- W2386291279 title "Effects of Calcipotriene,Tretinoin and Triptolide on Production of Vascular Endothelial Growth Factor in Keratinocytes and COLO16 Cell Line" @default.
- W2386291279 hasPublicationYear "2002" @default.
- W2386291279 type Work @default.
- W2386291279 sameAs 2386291279 @default.
- W2386291279 citedByCount "0" @default.
- W2386291279 crossrefType "journal-article" @default.
- W2386291279 hasAuthorship W2386291279A5010729427 @default.
- W2386291279 hasAuthorship W2386291279A5021920268 @default.
- W2386291279 hasAuthorship W2386291279A5055207211 @default.
- W2386291279 hasConcept C104317684 @default.
- W2386291279 hasConcept C105580179 @default.
- W2386291279 hasConcept C126322002 @default.
- W2386291279 hasConcept C153911025 @default.
- W2386291279 hasConcept C167734588 @default.
- W2386291279 hasConcept C185592680 @default.
- W2386291279 hasConcept C190283241 @default.
- W2386291279 hasConcept C2777025900 @default.
- W2386291279 hasConcept C2781164371 @default.
- W2386291279 hasConcept C54355233 @default.
- W2386291279 hasConcept C55493867 @default.
- W2386291279 hasConcept C71924100 @default.
- W2386291279 hasConcept C81885089 @default.
- W2386291279 hasConcept C86803240 @default.
- W2386291279 hasConceptScore W2386291279C104317684 @default.
- W2386291279 hasConceptScore W2386291279C105580179 @default.
- W2386291279 hasConceptScore W2386291279C126322002 @default.
- W2386291279 hasConceptScore W2386291279C153911025 @default.
- W2386291279 hasConceptScore W2386291279C167734588 @default.
- W2386291279 hasConceptScore W2386291279C185592680 @default.
- W2386291279 hasConceptScore W2386291279C190283241 @default.
- W2386291279 hasConceptScore W2386291279C2777025900 @default.
- W2386291279 hasConceptScore W2386291279C2781164371 @default.
- W2386291279 hasConceptScore W2386291279C54355233 @default.
- W2386291279 hasConceptScore W2386291279C55493867 @default.
- W2386291279 hasConceptScore W2386291279C71924100 @default.
- W2386291279 hasConceptScore W2386291279C81885089 @default.
- W2386291279 hasConceptScore W2386291279C86803240 @default.
- W2386291279 hasIssue "4" @default.
- W2386291279 hasLocation W23862912791 @default.
- W2386291279 hasOpenAccess W2386291279 @default.
- W2386291279 hasPrimaryLocation W23862912791 @default.
- W2386291279 hasRelatedWork W2015536820 @default.
- W2386291279 hasRelatedWork W2139563130 @default.
- W2386291279 hasRelatedWork W2143554109 @default.
- W2386291279 hasRelatedWork W2147641426 @default.
- W2386291279 hasRelatedWork W2348983994 @default.
- W2386291279 hasRelatedWork W2351911266 @default.
- W2386291279 hasRelatedWork W2356953935 @default.
- W2386291279 hasRelatedWork W2358784471 @default.
- W2386291279 hasRelatedWork W2363229567 @default.
- W2386291279 hasRelatedWork W2369683096 @default.
- W2386291279 hasRelatedWork W2373739497 @default.
- W2386291279 hasRelatedWork W2388299004 @default.
- W2386291279 hasRelatedWork W2391747974 @default.
- W2386291279 hasRelatedWork W2412595618 @default.
- W2386291279 hasRelatedWork W2746959705 @default.
- W2386291279 hasRelatedWork W2902684629 @default.
- W2386291279 hasRelatedWork W2977901122 @default.
- W2386291279 hasRelatedWork W3031882792 @default.
- W2386291279 hasRelatedWork W3036318901 @default.
- W2386291279 hasRelatedWork W901502311 @default.
- W2386291279 hasVolume "35" @default.
- W2386291279 isParatext "false" @default.
- W2386291279 isRetracted "false" @default.
- W2386291279 magId "2386291279" @default.
- W2386291279 workType "article" @default.