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- W2386301372 abstract "Objective To investigate anti-tumor effects of Buffalin on the transplantation tumor model of human pancreatic cancer in nude mice.Methods Transplantation tumor models of human pancreatic cancer were established on nude mice.Sixty models were randomly divided into 5 groups(n=12 in each group).Bufalin were injected intraperitoneally into the 2 groups at doses of 1.5,1.0 mg/kg respectively.NS group was injected with equal volume of saline as above and 5-Fu was injected intraperitoneally at a dose of 24mg/kg.Another group was injected with 5-Fu(24mg/kg)and Bufalin(1.0 mg/kg).Six mice in each group were killed after administration and the weight of mouse and tumor volume was examined.The survival time in each group was observed.Results The weight of nude mice in 5-Fu group and 5-Fu+Buf L group were reduced significantly(compared with Buf H and Buf L group,P0.01).The tumor volume in each group of Bufalin was reduced significantly(compared with NS group,P0.01),and Buf H group was reduced significantly(compared with Buf L group,P0.01),and 5-Fu+Buf L group was reduced significantly(compared with Buf H group,P0.01).The survival time prolonged in group Buf H and Buf L(compared with NS group,P0.05);.the apoptosis index in Buf H group was significantly higher than that of other groups(P 0.01)Conclusion Bufalin has significant anti-tumor effects on the transplantation tumor model of the human pancreatic cancer in nude mice.Induction of apoptosis of tumor cells might be one of the anti-tumor mechanisms of Bufalin." @default.
- W2386301372 created "2016-06-24" @default.
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- W2386301372 date "2007-01-01" @default.
- W2386301372 modified "2023-09-23" @default.
- W2386301372 title "Study on anti-tumor effects of Bufalin on the transplantation tumor model of the human pancreatic cancer in nude mice" @default.
- W2386301372 hasPublicationYear "2007" @default.
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