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- W2386301649 abstract "OBJECTIVE:To develop an LC-MS/MS (liquid chromatography with tandem mass spectrometry) method for determination of the serum concentration of carbamazepine in epileptic patients.METHODS:Serum sample was separated on Zorbax Extend-C18 chromatographic column,and the mobile phase consisted of methanol-0.01 mmol·L-1 amine acetic acid solution(80∶20) at a flow rate of 0.3 mL·min-1.The sample size was 10 μL.The electro-spray ionization source was used;the detection was performed in a positive ion model with positive ion monitoring served as the scanner mode.The collision-induced dissociation(CID) voltage of carbamazepine was set at 30 V,and the ionic reactions for quantitative analysis were m/z 237.2→m/z 194.2.RESULTS:The linear range of carbamazepine was 2.0～40.0 ng·mL-1(r=0.997 4),with its average recovery rate at 101.1%;the intra-day RSD and inter-day RSD of it were 3.39% and 4.11%,respectively.The mean serum concentration of carbamazepine in 10 epileptic patients were 5.69 ng·mL-1(RSD=4.75%),with a RSD level lower than that determined by fluorescence polarization immunoassay (FPIA).CONCLUSION:This method is specific,sensitive,reproducible,easy to operate and accurate in results,thus it is applicable for determination of serum concentration of carbamazepine." @default.
- W2386301649 created "2016-06-24" @default.
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- W2386301649 date "2009-01-01" @default.
- W2386301649 modified "2023-09-26" @default.
- W2386301649 title "Determination of Serum Concentration of Carbamazepine in Epileptic Patients by LC-MS/MS" @default.
- W2386301649 hasPublicationYear "2009" @default.
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