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- W2386308687 abstract "Objective:To study the subacute toxicity,genetic toxicity and hypotensive effect of monascus vinegar.Methods:A subacute toxic study in rats was performed by setting 3 different dose groups with 2.5,5.0,10.0 ml/kg.The genetic toxicity of monascus vinegar was observed by Ames test,micronucleus test of bone marrow cells in mice and sperm shape abnormality test in mice.0.5,1.0,3.0 ml/kg dose groups and vinegar control group were setting for observing the hypotensive effect of monascus vinegar for 4 weeks, Systolic blomt pressure(SBP)and heart rate(HR) were measured once a week.Results:There were no obvious subacute toxicity and genetic toxicity in all treated groups.Monascus vinegar has no obvious effect on SBP and HR in normal rats.Compared with the 0 ml/kg and vinegar control group,the SBP of 3.0 ml/kg group at the 3rd week and 1.0,3.0 ml/kg group at the 4th week time were decreased significantly.There were no obvious effect on HR of SHR in all monascus vinegar groups.Conclusion:Under this experimental conditions,it showed that monascus vinegar has no subacute toxicity and genetic toxicity,but also has the hypotensive effect in SHR." @default.
- W2386308687 created "2016-06-24" @default.
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- W2386308687 date "2009-01-01" @default.
- W2386308687 modified "2023-09-28" @default.
- W2386308687 title "Study on toxicity and hypotensive effect of monascus vinegar" @default.
- W2386308687 hasPublicationYear "2009" @default.
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