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- W2386312672 abstract "Objective To explore the effect of Norcantharidin(NCTD)on growth and invasion of GBC-SD cell line of human gallhladder carcinoma.Methods GBC-SD cell line of human gallbladder carcinoma was cultivated in vivo.Six NCTD groups of different concentrations(6 wells in each group)were divided and a control group(n=6)was set up.The killer inhibitory rote,invasion motion capability,cell cycle and apoptosis rate of NCTD on GBC-SD cells were determined by MTr method,Matrigel experiment,the crossing-river experiment,and FCM test.Results NCTD had obvious inhibitory effect on GBC-SD growth with the 50% inhibition concentration(IC_(50))being 56.18μg/ml.It inhibited GBC-SD invasion and migrated motion capability at the concentration of 5μg/ml.The inhibitory effect of NCTD increased,crossed cells of GBC-SD reduced,the dead crossed cells increased,and the crossing-river time obviously prolonged along with the increase of concentration(P0.01),showing certain dose-time effect relationship.FCM analysis showed cells in G_2+M stage ob- viously increased in NCTD group,while they decreased in S stage with increased cell apoptosis.Conclusion NCTD not only inhibited the GBC-SD cell growth of human gallblader carcinoma,but also could inhibit its invasive capability under lower concentration.Its mechanism might be related to the inhibition of GBC-SD cell proliferation,interference growth cy- cle,inhibiting DNA synthesis,inducing cell apoptosis,and directly inhibiting the GBC-SD migration." @default.
- W2386312672 created "2016-06-24" @default.
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- W2386312672 date "2004-01-01" @default.
- W2386312672 modified "2023-09-24" @default.
- W2386312672 title "Effect of Norcantharidin on Growth and Invasion of GBC-SD Cell Line of Human Gallbladder Carcinoma" @default.
- W2386312672 hasPublicationYear "2004" @default.
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