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- W2386344595 abstract "Objective To determine the effects of repair of mesothelium polarity on cancer cell inhibition.Methods Serial animal and cytological experiments,including cell polarity repair test,alimentary tract anastamosis healing test,T-tube fistula formation test,assessment of the parameters associated with cellular polarity repair and immortal cell(human bladder cancer cell line T24) inhibition,were employed in the control trials by using SurgetakeTM and normal saline.Results The experiments on rabbits evidenced a markedly higher proportion of complete repair of cellular polarity in SurgetakeTM group(n=10) than that in control group(P0.01).SurgetakeTM more potently potentiated the t-PA activity in vivo [(1.6±0.8)IU/ml vs(0.9±0.4)IU/ml],P0.01) and yielded a higher cell count in three visual fields when compared with normal controls(2995 vs 844,P0.05),as evidenced by immortalized cell inhibition test.Conclusion SurgetakeTM achieves mesothelium reconstruction by retaining tissue polarity and benefits the tissue repair from elevated t-PA activity leading to potentiated cellular polarity.The fact that maintenance of polarity correlate considerably with t-PA,a low molecular weight protein,indicates reduced malignancy via cellular polarization." @default.
- W2386344595 created "2016-06-24" @default.
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- W2386344595 date "2013-01-01" @default.
- W2386344595 modified "2023-09-26" @default.
- W2386344595 title "Surgitake~(TM) for repair of mesothelium polarity and cancer cell inhibition:an experimental study" @default.
- W2386344595 hasPublicationYear "2013" @default.
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