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- W2386371570 abstract "Objective To investigate the stem cell chemokine SDF-1 in the regulation of wound healing migration of epidermal stem cells to promote wound healing process.Methods Rat dorsal full-thickness skin defects were randomly divided into three experimental groups:①SDF-1 group;②AMD3100(CXCR4 receptor antagonist) group;③ control group.1 day,3 days,5 days,7 days and 12 days after injury camera calculates the wound at different times,and total percentage of the initial wound drawn.Using HE staining and immunohistochemical observation of a margin of epidermal migration and differentiation of stem cell characteristics,to find its own rules.Results Compared with the other two treatment groups,SDF-1 treatment to shorten healing time,the margin of skin epidermal basal cell division and proliferative margin of the number of epidermal stem cells was more than the other two groups.Conclusion In the wound healing process,SDF-1 can regulate epidermal stem cells migrate to the wound edge,accelerate wound epithelization." @default.
- W2386371570 created "2016-06-24" @default.
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- W2386371570 date "2010-01-01" @default.
- W2386371570 modified "2023-09-27" @default.
- W2386371570 title "SDF-1 accelerates wound healing via recruitment of epidermal stem cells" @default.
- W2386371570 hasPublicationYear "2010" @default.
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