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- W2386381624 abstract "To investigate the effects of polygonatum polysaccharide(PP) on the immunological activities in the immunosuppressed mice,forty ICR mice were divided into five groups: normal control,model(immunosuppressive mice),and L-,M-,H-dosage(100,400,800 mg/kg) PP.The mice were given once per day for 20 days by intragastric administration of PP solution.Beyond normal group,the mice of other groups were injected through peritoneal cavity 6 mg/kg of cyclophosphamide(Cy) on 3rd,6th.The immunity indexes were determined as follows: the swelling of ears,phagocytic index of peritoneal macrophages,the hemolysin,the weight of immune organs,the SOD activity and the MDA content in serum.To compare with normal group,the model group of immunosuppressive mice were induced successfully by 6 mg/kg of Cy.To compare with model group,PP could repair and enhance significantly the response of delayed-type hypersensitivity,the organ index,Phagocytic index and hemolysin indexsof mice(P 0.05),and there was an obviously dose-dependent relationship.Specifically,the activity of SOD serum(231.71 ± 7.75) U/mL in h-PP group almost reached or even exceeded that of normal mice.Additionally,contents of MDA(6.20 ± 0.65) nmol/mL were far lower than those of normal mice.The PP can reverse and repair obviously the immune function of the immunosuppressive mice induced by Cy.The polygonatum can be developed into the adjuvant therapeutic agent in chemotherapy." @default.
- W2386381624 created "2016-06-24" @default.
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- W2386381624 date "2013-01-01" @default.
- W2386381624 modified "2023-09-26" @default.
- W2386381624 title "Experimental Study of the Effects of Polygonatum Polysaccharides on Immunological Activities of Immunosuppressive Mice" @default.
- W2386381624 hasPublicationYear "2013" @default.
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