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- W2386388718 abstract "Hypoxia-inducible factors(HIF) are key regulators of the hypoxic responses. The HIF prolyl hydroxylases and asparaginyl hydroxylase regulate HIF function in terms of both protein stability and transcriptional potency by hydroxylating the special proline and asparagine residues. Hypoxia, as a major component, is involved in many diseases and have both proliferative (cancer-causing) or destructive effects (stroke, heart attack) in the pathogenesis. The use of pharmacological inhibitors of hydroxylases may offer a new alternative for the disease treatment." @default.
- W2386388718 created "2016-06-24" @default.
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- W2386388718 date "2004-01-01" @default.
- W2386388718 modified "2023-09-23" @default.
- W2386388718 title "Regulation of Hypoxia-inducible Factors by Prolyl and Asparaginyl Hydroxylases" @default.
- W2386388718 hasPublicationYear "2004" @default.
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