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- W2386400058 abstract "AIM: To observe the influence of dehydroepiandrosterone (DHEA) on the disordered function of ECV304 cells induced by LDL and OX - LDL, and to investigate the mechanisms of its possible anti - atherosclerosis. METHODS: The content of NO2-/NO3- and ET - 1 in culture medium and the ICAM - 1 expression of ECV304 cells pretreated by DHEA, or DHEA and LDL or OX-LDL were observed. The content of NO2- /NO3- and ET - 1 in medium was detected by colormetric method and radioimmunoassay. The expression of ICAM- 1 was detected immunohistochemically. RESULTS: LDL significantly reduced the content of NO2- /NO3- and increased the ICAM-1 expression in ECV304 cells while did not affect the level of ET - 1. OX - LDL obviously reduced the content of NO2- /NO3-, increased the level of ET-1 and increased the ICAM-1 expression in ECV304 cells. On the condition of pretreatment, DHEA increased the content of NO2-/NO3-and downregulated ICAM - 1 expression in ECV304 cells injured by LDL. However, on the mixture condition, DHEA had no protective effect on these cells. DHEA increased the content of NO2-/NO3- in culture medium, decreased the level of ET-1 and downregulated ICAM-1 expression in ECV304 cells injured by OX - LDL in the condition of pretreatment or mixture. CONCLUSION: LDL and OX - LDL have obviously cytotoxic effects on ECV304 cells, the mechanisms of which are different. DHEA may exert its protective effect on ECV304 cells by adjusting cells' inner structure and function or directly changing the structure of OX - LDL molecule." @default.
- W2386400058 created "2016-06-24" @default.
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- W2386400058 date "2005-01-01" @default.
- W2386400058 modified "2023-09-22" @default.
- W2386400058 title "Effect of DHEA on disordered function of ECV304 cells induced by LDL and OX-LDL" @default.
- W2386400058 hasPublicationYear "2005" @default.
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