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- W2386406032 abstract "Objective: To preparation of quaternized chitosan(QC)/alginate(ALG) complex nanoparticles with BSA. Therefore, it is necessary to establish an approach for fabricating an efficient controlled release drug delivery system. Methods: Under the condition of ultrasonic, preparation of different mass ratio with silicate chitosan intercalated structure complex nanoparticles. Morphology, infrared spectrum analysis, and the encapsulation efficiency and the loading capacity of nanoparticles were investigated. Results: OREC-HTCC nanoparticles were prepared successfully and universally spherical with a diameter of approximately 30 nm. FT-IR results confirmed that HTCC chains had intercalated into the interlayer of OREC and BSA was encapsulated by nanoparticles prepared by HTCC-ALG/OREC mixed material. After introduction of OREC, encapsulation efficiency and drug load of nanoparticles were significantly enhanced. However, encapsulation efficiency and drug load declined with the increase of OREC introduction. Conclusion: The nanoparticles prepared by HTCC-OREC have been used as drug carrier for protein, have the advantages of small size, high encapsulation efficiency and slow release. It provides scientific data for modulating the release of oral drug. It could be expected to be potential drug delivery system though there were few related reports." @default.
- W2386406032 created "2016-06-24" @default.
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- W2386406032 date "2014-01-01" @default.
- W2386406032 modified "2023-09-26" @default.
- W2386406032 title "Preparation of Quaternized Chitosan (QC)/alginate (ALG) Complex Nanoparticles" @default.
- W2386406032 hasPublicationYear "2014" @default.
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