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- W2386412684 abstract "Objective To study the mechanism of inflammatory cytokines in the cerebral ischemia-reperfusion injury.Methods Rats were subjected to cerebral ischemia-reperfusion induced by a middle cerebral artery occlusion(MCAO) with Longa's methods.At 6h,24h,3d and 7d after reperfusion,infarct size was determined by 2,3,5-triphenyi terazoloride(TTC) staining method,the data of TNF-α and IL-6 were determined in ipsilateral and contralateral cerebral hemisphere and serum by enzyme linked immunosorbent assay(ELISA),compared with sham-operated group respectively.Results TNF-α in ipsilateral and contralateral brain tissue increased significantly in early ischemia-reperfusion and peaked at 3d,IL-6 elevated a little later than TNF-α and peaked at 24h.No distinctive difference was observed in bilateral hemisphere.The changes of inflammatory cytokines in serum were less and lagged than that in brain.Accordant changes of infarct size and edema were found.Conclusion The inflammatory reaction appears in the pathologic development of focal cerebral ischemia-reperfusion injury and spreads throughout all brain and body." @default.
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- W2386412684 date "2009-01-01" @default.
- W2386412684 modified "2023-09-28" @default.
- W2386412684 title "Study on cytokine changes of brain and serum in rats with cerebral ischemia-reperfusion" @default.
- W2386412684 hasPublicationYear "2009" @default.
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