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- W2386433188 abstract "Aim: To probe the changes of γ-aminobutyric acid (GABA) and cyclic nucleotides (cAMP, cGMP) in morphine addicted mice brain caused by bovine acidic neuropeptide 1(BANP-1). Methods:A total of 48 Kunming mice were allocated into four groups,12 in each group.Three of the groups were injected with hydrochloric morphine at 100 mg/kg for 10 days.The 4th group was injected normal saline as control.On the 11th day,the morphine addicted group,abstinence group, BANP-1 group,and control group were given hydrochloric morphine,hydrochloric morphine and naloxone,hydrochloric morphine and BANP-1,and normal saline ,respectively.Then the mice were killed and the brain tissue was collected and homogenated to extract GABA and cyclic nucleotides for examination.GABA was analyzed by filter paper-electrophoresis method. cAMP and cGMP were analyzed by radioimmunity method.Results:Compared with that of control group,the morphine addicted groups had no significant difference in GABA,cAMP and cGMP(P0.05). cAMP and cGMP of abstinence group increased significantly (P0.05).Compared with those of control and abstinence group, GABA and cGMP of BANP-1 group were higher(P0.01). Conclusion: BANP-1 can exert actions through adjusting the concentrations of GABA and cGMP in morphine addicted mice." @default.
- W2386433188 created "2016-06-24" @default.
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- W2386433188 date "2005-01-01" @default.
- W2386433188 modified "2023-09-23" @default.
- W2386433188 title "Influence of bovine acidic neuropeptide 1 on GABA and cyclic nucleotides in brain tissue of morphine addicted mice" @default.
- W2386433188 hasPublicationYear "2005" @default.
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