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- W2386434038 abstract "Objective To observe and investigate the eosinophil(Eos) percentage of induced sputum in persistent asthma with different severity and stable stages, and the correlation between Eos percentage and lung function. Methods The 63 patients with persistent asthma newly diagnosed were recruited from special clinic. The range of disease severity was classified into mild, moderate and severe persistent according to the symptoms. Sputum was induced by hypertonic saline aerosol inhalation, and lung function was examed in all patients. The airway inflammation of patients with different severity of asthma was determined. All of the data acquired was analyzed by SPSS 15.0 software. Data among groups was compared by Kruskal-Wallis test; Mann-Whitney U test was used for the comparison between two groups. The correlation between Eos counting and lung function was assessed by Spearman rank-order method. Results ①There was progressively increasing percentage of Eos in induced sputum which related to asthma severity in persistent steroid-naive asthmatic patients. The percentage of Eos in induced sputum from severe asthmatics(41.8%) was significantly higher than that from mild asthmatics(17.8%, P=0.033). However, there was no significant difference between mild and moderate asthmatics, nor moderate and severe asthmatics(P0.05). ②In mild, moderate and severe asthmatics groups, percentage of Eos in induced sputum neither correlated with FEV1(r=-0.111, P0.05), nor correlated with FEV1/FVC(r=-0.154, P0.05). Conclusion The percentage of Eos in induced sputum correlated with severity of persistent asthmatics. However, symptoms could not reflect the airway inflammation accurately. We should combine the clinical symptoms with airway inflammation to assess the severity of asthma patients." @default.
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- W2386434038 date "2010-01-01" @default.
- W2386434038 modified "2023-09-24" @default.
- W2386434038 title "The relationship between persistent asthma severity and eosinophil percentage in induced sputum" @default.
- W2386434038 hasPublicationYear "2010" @default.
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