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- W2386467304 abstract "Objective: To investigate the effect of TNF-α and IFN-γ on NIT-1 cells apoptosis and the apoptosis mechanism. Methods: NIT-1 cells were exposed to a combination of TNF-α and IFN-γ treatment. The viability of NIT-1 cells was assessed via MTT assay. The morphological changes of the cells and nuclei were observed under the inverted or confocal laser scanning microscope with Hoechst 33258 staining. The activation of Caspase-8,-3 and PARP was detected by Western blot. Results: TNF-α and IFN-γ significantly inhibited NIT-1 cells viability,promoted cells apoptosis,induced the activation of Caspase-8,-3 and PARP cleavage. Conclusion: TNF-α combined with IFN-γ treatment induced the apoptosis of NIT-1 cells through death receptor pathway." @default.
- W2386467304 created "2016-06-24" @default.
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- W2386467304 date "2014-01-01" @default.
- W2386467304 modified "2023-09-26" @default.
- W2386467304 title "TNF-α enhances IFN-γ-induced NIT-1 cells apoptosis via death receptor pathway" @default.
- W2386467304 hasPublicationYear "2014" @default.
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