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- W2386496971 abstract "Objective To study the changes of PN and P105 expressions in arterial wall injury induced by lipidperoxidation.Methods The rat model of arterial wall injury induced by lipidperoxidation was prepared by intraperitoneal injections of Adriamycin in various dosages.The serum content of malondialdehyde (MDA) was estimated with thiobarbituric acid.```````` .RT?PCR was performed to analyze the expressions of fibronectin mRNA(FN) and P105 coactivator mRNA in the aorta.Results MDA contents in the middle and high ADR dose groups were higher than that in the control group ( P 0.05, P 0.01).FN mRNA and P105 mRNA expressions were higher in all ADR groups.Conclusion The higher expressions of FN and P105 are shown in all rat models of arterial wall injury induce by intraperitoneal injections of Adriamycin.It is proposed that lipidperoxidation might induce arteriosclerosis through multiple pathways." @default.
- W2386496971 created "2016-06-24" @default.
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- W2386496971 date "2002-01-01" @default.
- W2386496971 modified "2023-09-23" @default.
- W2386496971 title "The Change of FN and P105 Expressions in Arterial Wall Injury Induced by Lipidperoxidation" @default.
- W2386496971 hasPublicationYear "2002" @default.
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