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• W2386504815 abstract "Objective:Detect the clinical high risk factors of fetal chromosomal abnormalities by analysis of karyotypically with amniocentensis,increasing the detect rate of aminiocentensis.Methods:recruiting 555 preganant women during 18 to 24 gestational weeks,besides 5,they have the indication of aminiocentensis include:age is or over 35 years,delivered chromosomal abnormalities baby before,serum screening show high risk,ultrasound softer marker abnormal,one of the couple developed chromosomal abnormalities or exposed to harmful environments and getting amniocentensis in The Prenatal Diagnose Center of Beijing Obstetric and Gynecological Hospital,analysis the karyotypically of fetal cast-off cells cultivated by orthotope slice and G band staining technique.Analysis the data by SPSS 11.5 softy ware.Result:There are 15 chromosomal abnormalities,6 18-trisome,6 21-trisome,1 XYY,1 unbanlenced translocation,1banlenced translocation.The incidence of chromosomal abnormalities in serum screening high risk is 2.09%,it is 2.37% in the senior preganant group,no significantly difference of chromosomal abnormalities between the two groupes(P=0.600).The incidence of chromosomal abnormalities increase obviously when the pregnants elder than 40 years.The average of father's age in the chromosomal abnormalities group is about 39 years elder than that in normal chromosomal group 36 years old(P=0.044),but this result is affected by the age of mother,because of excluding senior preganant,the age of father appeared no significant difference during the normal and abnormal chromosomal group.The significantly difference also appeared between the normal and abnormal ultrasound measurement group(P=0.000).The ultrasound marker considered as abnormal echo in ventricle,intensification of intestine echo,pelviectasis,neck diaphanotheca thickening,choroid plexus cyst,gastric vacuole not appearing etc.There are 20 cases appeared positive soft marker,and 5 are chromosomal abnormalities 23.8%(5/20),the rate of detection higher than that of normal ultrasound group 1.9%(10/524),it is significant difference(P=0.000),same as the difference between the abnormal ultrasound cases and the serum screening high risk group(P=0.0003).Comparing the vaginal bleeding rate of early preganant,no significant difference appeared between the normal and abnormal chromosomal karyotypically groups.Conclusion:Because of the maternal serum β-HCG、AFP level changing with different gestational week,verifing the exact gestational week is very important during serum screening.Ultrasound screening is necessary as early as possible for menstruation irregularis after menolipsis.Both women with serum screening high risk and 35 years of age or older,especially over 40 years should be performed prenatal diagnose.The ultrasound marker in the second trimester should be concerned as a screening marker." @default.
• W2386504815 created "2016-06-24" @default.
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• W2386504815 date "2008-01-01" @default.
• W2386504815 modified "2023-09-23" @default.
• W2386504815 title "Clinical study of prenatal diagnosis for chrmonsomal abnoralities by amniocentensis of 555 cases" @default.
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