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- W2386508775 abstract "Objective: To evaluate the efficacy and safety of a zaleplon recently approved nonbenzodiazepine hypnotic in the treatment of primary insomnia, and to observe rebound insomnia upon discontinuation of therapy. Methods: A multicenter, randomized, double-blind, active drug-comparator parallel study with both 5mg and 10mg dose were carried out. 48 patients who met the CCMD-2-R criteria of primary insomnia were entered the study. The 24 cases of total patients were treated with zaleplon (5～10?mg/d) and the others were treated with zolpidem (10mg/d) for 2 weeks. The efficacy was evaluated by clinical judgment, SDRS, CGI,et al. The safety was assessed in terms of TESS. Results: By the end of this study, the scores of sleep dysfunction rating scale (SDRS) were significantly lower through 3 weeks of treatment than datum line (P0 01), the rate of efficacy and marked improved rate respectively were 79 17% and 25 00% for zolpidem, 77 27% and 36 36% for zaleplon. There was no significant difference in any efficacy measurement between zaleplon group and zolpidem group. The main side-effects of both groups were dizziness, dry mouth, headache, somnolence, anorexia, et al. There was no significant difference in incidence of side effect between zaleplon group and zollidem group. Conclusion: Zaleplon is an effective hypnotics with less side effects and better safety." @default.
- W2386508775 created "2016-06-24" @default.
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- W2386508775 date "2003-01-01" @default.
- W2386508775 modified "2023-09-24" @default.
- W2386508775 title "The Second Phase Clinical Trials of the Second Category Novel Hypnotic, Zaleplon for the Treatment of Insomnia" @default.
- W2386508775 hasPublicationYear "2003" @default.
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