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- W2386519005 abstract "Scrapie is a kind of transmissible spongiform encephalopathies(TSE)involving in sheep and goat. To study the characteristics of the infectious agent and the neuropathology, Scrapies agent 263K was inoculated into the brains of the hamsters. 81 to 110 days after inoculation, 89% animals(17/19)appeared typical symptoms of TSE. Neuropathological studies revealed that 59% infected hamsters showed spongiform degeneration and 17% showed amyloid plaques. By immunohistochemistry and proteinase K-digested Western blot, the proteinase-resistant PrP-res proteins were detected in the brain tissues from all the infected animals. The electrophoresis patterns and the evaluated molecular weights of the PrP-res proteins from 17 infected hamsters were all the same, presenting two bands between roughly 25 kD and 31 kD in Western blot assays. Moreover, imprints of fresh brain tissues on slides were tested for PrP-res proteins. It showed similar results as that of routinely used paraffin-embedded slides by immunohistochemistry assays, which implies that this technique might be an effective method to detect PrP-res in the brain biopsies of the patients with CJD. Successful infection of Scrapie agent 263K in hamsters confirmed that baby hamster is an ideal model for TSE agents, with shorter incubation period and higher morbidity. The detecting rate of PrP-res is clearly higher than that of the neuropathological changes in the brain tissues from the infected animals. The electrophoresis patterns of the newly formed PrP-res proteins depend on the inoculated TSE agents, but not the individual animals, suggesting that there might be various “strains among TSE agents." @default.
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- W2386519005 date "2001-01-01" @default.
- W2386519005 modified "2023-09-27" @default.
- W2386519005 title "PrP-res Protein and Neuropathological Analyses of the Brain Tissues from Hamsters Infected with Scrapie 263K" @default.
- W2386519005 hasPublicationYear "2001" @default.
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