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- W2386529415 abstract "Objective To observe the analgesic effect and the acute toxicity effect of Xiaotongn- ing capsule. Methods Using the hot-plate method and the writhing assay in mice,the analgesic effect and the acute toxicity effect of Xiaotongning capsule were observed. Results Compared with the con- trol group, the 500 mg/kg group, at 240 min, the pain threshold was able to increase in the hot-plate test(P0.05). While in the 1 000, 1 500 mg/kg group,even at 60 min,the pain threshold was able to in- crease in the hot-plate test (P0.05), as time extending a remarkable delay effect was observed,and that peaked in the period between 120~240 min (P0.01) and in the 1 500 mg/kg group peaked between 180 ~240 min (P 0.01). Xiaotongning capsule 500.100,1 500 mg/kg elicited inhibiting acetic acid writhing response significantly 70~80 min after administration (P0.001). The acute toxicity experiment of administration of Xiaotongning capsule showed:the maximum tolerant dose was 60 g/kg for mice. Conclusion These results suggest that Xiaotongning capsule possesses analgesic effect for both pe- ripheral and central nervous system, and the maximum tolerant dose is 60 g/kg for mice." @default.
- W2386529415 created "2016-06-24" @default.
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- W2386529415 date "2008-01-01" @default.
- W2386529415 modified "2023-09-26" @default.
- W2386529415 title "Study on Analgesic Effect and Acute Toxicity of Xiaotongning Capsule" @default.
- W2386529415 hasPublicationYear "2008" @default.
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