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- W2386544149 abstract "Objective:To study the inhibitory effects of ligustrazine on adhesion,migration and invasion of human acute lymphoblastic leukemia(ALL) cell line Jurkat.Methods:Jurkat cells were cultured in vitro and treated by 50μg/ml,100μg/ml and 150μg/ml ligustrazine respectively.Then the adhesion,migration and invasion of Jurkat cells were measured with cell adhesion test,cell migration test and cell invasion test.The measurement data was collected and the multi-samples were analyzed by analysis of variance(One-Way ANOVA).Results:Compared with control group,50μg/ml,100μg/ml and 150μg/ml ligustrazine could significantly inhibit the migration of Jurkat cells and their invasion to basement membrane(P0.01),and 100μg/ml and 150μg/ml ligustrazine could effectively inhibit adhesion of Jurkat cells to fibronectin(P0.01) but the function of 50μg/ml ligustrazine was not obvious(P0.05).Conclusion:By roundly inhibiting adhesion,migration and invasion of Jurkat cells,ligustrazine is a good inhibitor to leukemia and the inhibitory effects are dose dependent." @default.
- W2386544149 created "2016-06-24" @default.
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- W2386544149 date "2008-01-01" @default.
- W2386544149 modified "2023-09-24" @default.
- W2386544149 title "Effects of ligustrazine on adhesion,migration and invasion of Jurkat cells" @default.
- W2386544149 hasPublicationYear "2008" @default.
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