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- W2386546144 abstract "Objective: To develop a human colon carcinoma liver metastases model for experimental studies in nude mice ,CK20 mRNA in blood of nude mice was detected.Methods:liver metastases were established in twelve BALB/c nude mice by intrasplenic injection of colonic adenocarcinoma cells(Ls174t) with 1×10 6 cells in 0.1ml solution,the spleen wasn't left, after twenty days every mouse was killed.Blood was collected ,The growth and the number of the liver metastases were evaluated, the liver metastases were studied histologically. Using nested reverse transcript polymerase chain reaction(RT-PCR) technique CK20 mRNA in blood of 12 nude mice with liver metastases from colon carcinoma was detected. Results:During the whole experiment,all mice inoculated had lived,after 10 days, they became worse and worse. All mice inoculated with LS174t cell lines developed liver metastases,other organic metastases weren't observed.the pathological results showed that tumour cells of liver metastases accorded with poorly differentiated colonic adenocarcinoma,the expression of CK20 mRNA in blood of them was 12/12. Conclusion:Intrasplenic injection of Ls174t cells is a reliable model for producing colonic cancer liver metastases and should prove valuable in experimental study. The expression of CK20 mRNA in blood is a foundation of liver metastases from colon carcinoma in nude mice." @default.
- W2386546144 created "2016-06-24" @default.
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- W2386546144 date "2002-01-01" @default.
- W2386546144 modified "2023-09-25" @default.
- W2386546144 title "DEVELOPMENT OF A HUMAN COLON CARCINOMA LIVER METASTASES MODEL AND EXPRESSION OF CK20 mRNA IN BLOOD OF NUDE MICE" @default.
- W2386546144 hasPublicationYear "2002" @default.
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