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- W2386553919 abstract "Objective To reveal the correlative association of pancreatic expression of TGF β 1 and CTGF in chronic pancreatitis animal model. Methods The injection method of TNBS through rats' pancreatic duct was undertaken to set up the animal model of chronic pancreatitis; Col1 and FN were taken as the markers of matrix synthesis to evaluate the degrees of severity of pancreatic fibrosis by using immunohistochemistry in situ for hybridization. TGF β 1 and CTGF were also investigated by these methods to detect their pancreatic expression at the levels of transcription and translation with their mRNA and protein expressions. Results Injection of TNBS solution into rats' pancreatic duct caused changes such as duct dilatation, interstitial edema, infiltration of inflammatory cells and acinar cellular necrosis in the pancreatic tissue 3 weeks after wards. By the end of 4 weeks, the changes reached the peak level with formation of pancreatic fibrosis with no further increase in the degree of fibrosis later on. TGF β 1 was detected in the cytoplasm of the fibroblasts in the interstitial and some inflammatory areas with intensive expression of CTGF disseminating in the acinar epithelial cells and a portion of fibroblasts. The expression intensity of TGF β 1 and CTGF were corqrelated to the grade of fibrosis ( P 0.01).Conclusions The increasing level of pancreatic fibrosis formation is positively correlated with the expressions of TGF β 1 and CTGF, especially the CTGF as the downstream factor of TGF β 1, may play a key role in the processing." @default.
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- W2386553919 date "2004-01-01" @default.
- W2386553919 modified "2023-09-23" @default.
- W2386553919 title "Expression of profibrotic cytokines in the process of chronic pancreatitis" @default.
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