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- W2386568076 abstract "Immunoregulatory mechamisms of total glucosides of paeony(TGP)in adjuvant arthritic(AA)rats were studied.The results showed mat lower ConA-induced proliferative responses Of splenocytes,on the 14 th,21 th,and 28 th day respectively,were restored in AA rats treated with TGP(50 mg·kg-1 in X27d).By reconstituted culture,the diminished ConA-induced proliferative responses were found when 2.5% peritomeal macrophages(PMφ)from AA rats were added in the culture of Mφ-depleted splenocytes from AA rats of normal rats.At the same concentration of PMφ from AA rats administrated with TGP(50mg·kg-1·d-1ig×7d),however,the remarkable recovery of the diminished ConA-induced proliferative responses was observed,showing the regulatory actions of TGP in AA rats might be mediated via Mφ.The results also showed that elevated prostaglandin E2(PGE2) released from PMφ,on the 7th,14th,21th and 28th day respectively, were restored in the AA rats (50 mg·kg-1·d-1X27d).Analyses of PGE2and ConA-induced responses in AA rats by linear corelation, the corelated coefficient was found to be-0.55(P0.05),indicating that the recovery of elevated PGE2 might be one of the mechanisms of TGP,by which the diminished ConA-induced responses of splenocytes were restored in AA rats." @default.
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- W2386568076 date "1995-01-01" @default.
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- W2386568076 title "Immunoregulatory mechanisms of total glucosides of paeony in adjuvant arthritic rats" @default.
- W2386568076 hasPublicationYear "1995" @default.
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