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- W2386585348 abstract "Purpose To investigate the expression of nm23-H1,BRCA1,PTEN,cathepsin D,MMP-2,CD44v6 proteins and their clinical significance in human breast cancers.Methods The expressions of biological marker proteins were determined by immunohistochemical S-P staining in 106 cases of infiltrating breast cancers.Results In breast cancers,the expressions of CD44v6,MMP-2,cathepsin D were increased,the expression of nm23-H1,PTEN were decreased.The positive expressions of CD44v6,MMP-2 and the negative expression of nm23-H1,PTEN,BRCA1 were positively correlated with recurrence.There was a statistically significant correlation between cathepsin D expression of stromal cells and recurrence.In breast cancers,the expression of BRCA1 had positive correlation to that of nm23-H1,PTEN,and had negative correlation to that of MMP-2.The expression of MMP-2 had positive correlation to that of CD44v6.Conclusions Enhancement of MMP-2 expression,inhibition of nm23-H1 and BRCA1 expression may be the reliable markers for predicting tumor metastasis and prognosis." @default.
- W2386585348 created "2016-06-24" @default.
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- W2386585348 date "2005-01-01" @default.
- W2386585348 modified "2023-09-24" @default.
- W2386585348 title "Expression and clinical significance of biological markers associated with prognosis in breast cancers" @default.
- W2386585348 hasPublicationYear "2005" @default.
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