Matches in SemOpenAlex for { <https://semopenalex.org/work/W2386596985> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2386596985 abstract "Aim In order to study the change and role of apoptosis in hypertensive left ventricular remodeling. Methods Hearts from 16-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) were investigated. Apoptosis in left ventricle sections was assessed by an in situ end-labeling technique (TUNEL), the feature and type of cells undergoing apoptosis were identified ultrastructurally by transmission electron microscope (ECM). Additionally, localization of Fas protein- a mediator of apoptotic cell death was examined by immunohistochemistry. Results Compared with 16-week-old WKY, 16-week-old SHR exhibited increased hypertrophic index, the apoptotic frequency of myocytes was also increased(19.54±7.27 vs 6.92±4.35/104 nucleus,P0.05), whereas the apoptotic frequency of fibroblasts was significantly decreased (5.88±2.15 vs 14.34±9.56/104 nucleus, P0.05). Moreover, apoptotic endothelial cells and leukocytes infiltrated into myocardium were also identified in SHR. Features of apoptotic myocytes and endothelial cells were observed by ECM in SHR. The latter often occurred in shrunken capillaries surrounded by collagen fragments The distribution of Fas antigen protein was mainly confined to myocytes in SHR, but limited to interstitial fibroblasts in WKY, consistently with the type of cells undergoing apoptosis in these two strains. Conclusion This study first suggest that apoptosis of different cell type may work synthetically in hypertensive myocardial remodeling, and Fas antigen may be associated with the mechanisms of these apoptotic process. Our findings also have important significance in searching new avenues for treatment with appropriate site-specific physiological or pharmacological regulators of apoptosis." @default.
- W2386596985 created "2016-06-24" @default.
- W2386596985 creator A5027863398 @default.
- W2386596985 date "2001-01-01" @default.
- W2386596985 modified "2023-09-25" @default.
- W2386596985 title "Apoptosis in Left Ventricular Remodeling of Spontaneously Hypertensive Rats" @default.
- W2386596985 hasPublicationYear "2001" @default.
- W2386596985 type Work @default.
- W2386596985 sameAs 2386596985 @default.
- W2386596985 citedByCount "0" @default.
- W2386596985 crossrefType "journal-article" @default.
- W2386596985 hasAuthorship W2386596985A5027863398 @default.
- W2386596985 hasConcept C126322002 @default.
- W2386596985 hasConcept C134018914 @default.
- W2386596985 hasConcept C142724271 @default.
- W2386596985 hasConcept C185592680 @default.
- W2386596985 hasConcept C190283241 @default.
- W2386596985 hasConcept C196795494 @default.
- W2386596985 hasConcept C204232928 @default.
- W2386596985 hasConcept C207200792 @default.
- W2386596985 hasConcept C2778198053 @default.
- W2386596985 hasConcept C2778921608 @default.
- W2386596985 hasConcept C2779537366 @default.
- W2386596985 hasConcept C55493867 @default.
- W2386596985 hasConcept C71924100 @default.
- W2386596985 hasConcept C86803240 @default.
- W2386596985 hasConcept C95444343 @default.
- W2386596985 hasConceptScore W2386596985C126322002 @default.
- W2386596985 hasConceptScore W2386596985C134018914 @default.
- W2386596985 hasConceptScore W2386596985C142724271 @default.
- W2386596985 hasConceptScore W2386596985C185592680 @default.
- W2386596985 hasConceptScore W2386596985C190283241 @default.
- W2386596985 hasConceptScore W2386596985C196795494 @default.
- W2386596985 hasConceptScore W2386596985C204232928 @default.
- W2386596985 hasConceptScore W2386596985C207200792 @default.
- W2386596985 hasConceptScore W2386596985C2778198053 @default.
- W2386596985 hasConceptScore W2386596985C2778921608 @default.
- W2386596985 hasConceptScore W2386596985C2779537366 @default.
- W2386596985 hasConceptScore W2386596985C55493867 @default.
- W2386596985 hasConceptScore W2386596985C71924100 @default.
- W2386596985 hasConceptScore W2386596985C86803240 @default.
- W2386596985 hasConceptScore W2386596985C95444343 @default.
- W2386596985 hasLocation W23865969851 @default.
- W2386596985 hasOpenAccess W2386596985 @default.
- W2386596985 hasPrimaryLocation W23865969851 @default.
- W2386596985 hasRelatedWork W2008036308 @default.
- W2386596985 hasRelatedWork W2024325223 @default.
- W2386596985 hasRelatedWork W2030317008 @default.
- W2386596985 hasRelatedWork W2066325112 @default.
- W2386596985 hasRelatedWork W2067040803 @default.
- W2386596985 hasRelatedWork W2071531135 @default.
- W2386596985 hasRelatedWork W2088366145 @default.
- W2386596985 hasRelatedWork W2108398079 @default.
- W2386596985 hasRelatedWork W2151775533 @default.
- W2386596985 hasRelatedWork W2334572776 @default.
- W2386596985 hasRelatedWork W2361132890 @default.
- W2386596985 hasRelatedWork W2361591213 @default.
- W2386596985 hasRelatedWork W2365008579 @default.
- W2386596985 hasRelatedWork W2365426652 @default.
- W2386596985 hasRelatedWork W2371005592 @default.
- W2386596985 hasRelatedWork W2379742867 @default.
- W2386596985 hasRelatedWork W2599072964 @default.
- W2386596985 hasRelatedWork W3141926229 @default.
- W2386596985 hasRelatedWork W3162511125 @default.
- W2386596985 hasRelatedWork W2012344694 @default.
- W2386596985 isParatext "false" @default.
- W2386596985 isRetracted "false" @default.
- W2386596985 magId "2386596985" @default.
- W2386596985 workType "article" @default.