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• W2386597219 abstract "AIM To study the pharmacokinetics of rutoside in rabbits. METHODS After administration of rutoside (5 mg·kg-1, iv), the plasma concentration at different times were determined by fluorescence spectrophotometry. The data were proccssed with 3P87 pharmacokinetic procedure. RESULTS The concentrationtime (CT) equation is: C=859789 e-0.9044 T+345105 e-0.0587 T+43838 e-0.0046 T. The pharmacokinetic parameters are as follows: T1/2a:(07609±01066) min,T1/2b:(125667±37139) min,T1/2c:(1625651±506035) min,K12:(05123±01316) min-1,K21:(03298±00737) min-1,K13:(00739±00182) min-1,K31:(00100±00037) min-1,K10:(00774±00160) min-1, Vc:(00404±00044) L·kg-1,AUC:(16797583±4806045) mg·L-1·min,CLs:(00031±00008) L·kg-1·min-1. CONCLUSION In the body of rabbit, the CT change of rutoside conforms to an open three compartment model, the distribution and the elimination of rutoside are rapid." @default.
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• W2386597219 date "1998-01-01" @default.
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• W2386597219 title "Study on pharmacokinetics of rutoside" @default.
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