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- W2386600045 abstract "Objective:To investigate the changes and relationship of leukotriene B4(LTB4) and matrix metalloproteinase-9(MMP-9) patients in with acute coronary syndrome (ACS) and to explore the potential predictive factor for ACS. Method:LTB4 and MMP-9 were measured by enzyme-linked immunosorbent assay and blood-lipid and CRP were detected by automatic biochemistry analyzer in 65 patients with ACS and 20 healthy people.Result:LTB4 level was significant higher in patients with ACS( [112.77±22.59]ng/L in acute myocardial infarction (AMI) patients and [86.94±14.81] ng/L in unstable angina pectoris[UAP] patients respectively) than in control group[40.5±8.85]μg/L,P0.01), with the higher level in AMI than in UAP(P0.05). LTB4 was significantly positive correlated with MMP-9(r=0.875,P0.01),CRP(r=0.641,P0.01),TG(r=0.469,P0.01) and negative correlated with HDL-C(r=-0.370,P0.01).Conclusion:Plasma LTB4 and MMP-9 are elevated in ACS. LTB4 plays, a possible role in vascular inflarnmation neit involved in MMP-9 and CRP and lipid metabolic disorder, thus may serve as a potential risk factor for the stakility of atherosclerotic plaque of ACS." @default.
- W2386600045 created "2016-06-24" @default.
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- W2386600045 date "2007-01-01" @default.
- W2386600045 modified "2023-09-23" @default.
- W2386600045 title "Changes and significance of leukotriene B4 and matrix metalloproteinase-9 levels in patients with acute coronay syndrome" @default.
- W2386600045 hasPublicationYear "2007" @default.
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