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- W2386606669 abstract "Objective To investigate the relationship between the expression of glucosylceramide synthase(GCS) mRNA in human erythroleukemia cell line K562/AO2 and multidrug resistance of the tumor cells.Methods Alamar BlueTM multifunction cell staining method was applied to confirm the multidrug resistant of K562/AO2 cells.Using reverse transcript polymerase chain reaction(RT-PCR),the differential expressions of GCS mRNA,MDR1 mRNA,bcl-2 mRNA and bax mRNA between K562/AO2 and K562 cell lines were analyzed.Results(1) The IC50 of ADR to K562/AO2 and K562 cell line separately was 75 μg/ml and 0.65 μg/ml,the IC50 of VCR to K562/AO2 and K562 cell line separately was 8 μg/ml and 0.22 μg/ml.The drug resistance factor separately was 115 and 36.(2) K562/AO2 cells exhibited significantly higher expressions of GCS and MDR1 gene than K562 cells,and K562/AO2 cells exhibited higher expressions of bcl-2 gene than K562 cells whereas the expressions of bax gene were higher in K562 cells.Conclusion GCS gene might play an important role in MDR during human leukemia progression.Abnormal expressions of the genes in associated with cell apoptosis might be one of the main molecular pathology mechanisms of multidrug resistance caused by GCS gene." @default.
- W2386606669 created "2016-06-24" @default.
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- W2386606669 date "2007-01-01" @default.
- W2386606669 modified "2023-09-23" @default.
- W2386606669 title "Expressions of Glucosylceramide Synthase mRNA in Human K562/AO2 Cell Line in Association with Multidrug Resistance" @default.
- W2386606669 hasPublicationYear "2007" @default.
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