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- W2386611810 abstract "Rheumatoid arthritis(RA) is a chronic and debilitating autoimmune disease of unknown etiology,characterized by chronic inflammation in joints with subsequent destruction of cartilages and bones.Collagen-induced arthritis(CIA) is an ideal model for the experimental studies of RA on account of the fact that it shares a number of clinical,histological and immunological features with RA.In the present study,CIA model in Wistar rats was successfully established,and by using this animal model,the effect of injection with vasoactive intestinal peptide(VIP) to interfere with the development of arthritis was investigated.The experimental results revealed that the incidence and severity of CIA in rats treated with VIP were significantly reduced,abrogating the joint swelling and destruction of cartilages and bones.These data indicate that vasoactive intestinal peptide can inhibit the development of symptoms in arthritis through reducing the immune response to collagen,and it may be a potential candidate to develop the therapeutical strategies for rheumatoid arthritis." @default.
- W2386611810 created "2016-06-24" @default.
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- W2386611810 date "2006-01-01" @default.
- W2386611810 modified "2023-09-23" @default.
- W2386611810 title "Vasoactive intestinal peptide inhibits the development of experimental arthritis" @default.
- W2386611810 hasPublicationYear "2006" @default.
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