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- W2386617893 abstract "Objective This study was to evaluate the effect of sorafenib on human ovarian cancer cell SKOV-3.Methods MTT was used to examine the effects of sorafenib at different concentrations(1.5、3.0、6.0、12.0 and 24.0 μmol/L) and different time points(24、48 and 72 h) on proliferation of SKOV-3 cells.Hoechst 33258 staining assay was used to observe sorafenib-induced morphological changes.SKOV-3 cells were treated with sorafenib or paclitaxel alone or in three different schedules:sorafenib was given prior to,after or simultaneously with paclitaxel.Alteration of cell cycle and apoptosis were analyzed by flow cytometry.Results The results indicated that sorafenib could induce apoptosis of SKOV-3 cells and the apoptotic rate was increased with the increase of sorafenib concentration compared with the control group(P0.05).Sorafenib caused cell cycle arrest at S phase,S and G2/M phases were extended when sorafenib was in combination with paclitaxel.Conclusion Sorafenib can effectively inhibit the proliferation of SKOV-3 cells in time and dose dependent manners.Administration of sorafenib after paclitaxel induces a higher apoptotic rate in SKOV-3 cells than administration before or simutanously with paclitaxel." @default.
- W2386617893 created "2016-06-24" @default.
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- W2386617893 date "2012-01-01" @default.
- W2386617893 modified "2023-09-24" @default.
- W2386617893 title "Effects of Sorafenib in Combination with Paclitaxel on Apoptosis of Human Ovarian Cancer Cell Line SKOV-3" @default.
- W2386617893 hasPublicationYear "2012" @default.
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