Matches in SemOpenAlex for { <https://semopenalex.org/work/W2386621801> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2386621801 abstract "Objective To explore the multidrug resistance of a novel human monocytic leukemic cell line SHI-1 and its mechanisms.Methods The sensitivity of SHI-1 cell to various chemotherapeutic drugs was evaluated by thizolyl blue method(MTT).FCM was used to study the expression of P-glycoprotein(P-gp),multidrug resistance related protein(MRP),lung resistance protein(LRP),GST-π and breast cancer resistance protein(BCRP).Results The results of MTT disclosed that there was a multidrug resistance in the SHI-1 cell line especially for etoposide.The results of FCM showed that the SHI-1 cell line was positive for LRP(92.86%,RFI 8.00)and GST-π(93.52%,RFI 6.91),but negative for P-gp(10.78%,RFI 1.02),MRP(4.54%,RFI 1.38),and BCRP(3.84%,RFI 1.06).Conclusion The multidrug resistance is existed in the SHI-1 cell line especially for etoposide.The mechanism of multidrug resistance may be associated with the upregulation of expression of the LRP gene and the GST-π gene." @default.
- W2386621801 created "2016-06-24" @default.
- W2386621801 creator A5086532638 @default.
- W2386621801 date "2007-01-01" @default.
- W2386621801 modified "2023-09-24" @default.
- W2386621801 title "Preliminary study on multidrug resistance in a novel human acute monocytic leukemic cell line SHI-1" @default.
- W2386621801 hasPublicationYear "2007" @default.
- W2386621801 type Work @default.
- W2386621801 sameAs 2386621801 @default.
- W2386621801 citedByCount "0" @default.
- W2386621801 crossrefType "journal-article" @default.
- W2386621801 hasAuthorship W2386621801A5086532638 @default.
- W2386621801 hasConcept C104317684 @default.
- W2386621801 hasConcept C114851261 @default.
- W2386621801 hasConcept C133936738 @default.
- W2386621801 hasConcept C149011108 @default.
- W2386621801 hasConcept C153911025 @default.
- W2386621801 hasConcept C2776694085 @default.
- W2386621801 hasConcept C2778119113 @default.
- W2386621801 hasConcept C2778707650 @default.
- W2386621801 hasConcept C2780783641 @default.
- W2386621801 hasConcept C44312359 @default.
- W2386621801 hasConcept C502942594 @default.
- W2386621801 hasConcept C512196 @default.
- W2386621801 hasConcept C54355233 @default.
- W2386621801 hasConcept C55493867 @default.
- W2386621801 hasConcept C81885089 @default.
- W2386621801 hasConcept C86803240 @default.
- W2386621801 hasConcept C89423630 @default.
- W2386621801 hasConceptScore W2386621801C104317684 @default.
- W2386621801 hasConceptScore W2386621801C114851261 @default.
- W2386621801 hasConceptScore W2386621801C133936738 @default.
- W2386621801 hasConceptScore W2386621801C149011108 @default.
- W2386621801 hasConceptScore W2386621801C153911025 @default.
- W2386621801 hasConceptScore W2386621801C2776694085 @default.
- W2386621801 hasConceptScore W2386621801C2778119113 @default.
- W2386621801 hasConceptScore W2386621801C2778707650 @default.
- W2386621801 hasConceptScore W2386621801C2780783641 @default.
- W2386621801 hasConceptScore W2386621801C44312359 @default.
- W2386621801 hasConceptScore W2386621801C502942594 @default.
- W2386621801 hasConceptScore W2386621801C512196 @default.
- W2386621801 hasConceptScore W2386621801C54355233 @default.
- W2386621801 hasConceptScore W2386621801C55493867 @default.
- W2386621801 hasConceptScore W2386621801C81885089 @default.
- W2386621801 hasConceptScore W2386621801C86803240 @default.
- W2386621801 hasConceptScore W2386621801C89423630 @default.
- W2386621801 hasLocation W23866218011 @default.
- W2386621801 hasOpenAccess W2386621801 @default.
- W2386621801 hasPrimaryLocation W23866218011 @default.
- W2386621801 hasRelatedWork W1979332941 @default.
- W2386621801 hasRelatedWork W2021750163 @default.
- W2386621801 hasRelatedWork W2043303451 @default.
- W2386621801 hasRelatedWork W2069888472 @default.
- W2386621801 hasRelatedWork W2085004273 @default.
- W2386621801 hasRelatedWork W2105436547 @default.
- W2386621801 hasRelatedWork W2108415554 @default.
- W2386621801 hasRelatedWork W2349906479 @default.
- W2386621801 hasRelatedWork W2353343827 @default.
- W2386621801 hasRelatedWork W2361435800 @default.
- W2386621801 hasRelatedWork W2364896153 @default.
- W2386621801 hasRelatedWork W2365940751 @default.
- W2386621801 hasRelatedWork W2366418981 @default.
- W2386621801 hasRelatedWork W2368154612 @default.
- W2386621801 hasRelatedWork W2381486700 @default.
- W2386621801 hasRelatedWork W2383322884 @default.
- W2386621801 hasRelatedWork W2581230728 @default.
- W2386621801 hasRelatedWork W2589869850 @default.
- W2386621801 hasRelatedWork W2771716313 @default.
- W2386621801 hasRelatedWork W52369712 @default.
- W2386621801 isParatext "false" @default.
- W2386621801 isRetracted "false" @default.
- W2386621801 magId "2386621801" @default.
- W2386621801 workType "article" @default.