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- W2386622979 abstract "Objective: To evaluate the possible effects of single oral administration of sterigmatocystin (ST) on the ependymal cell ultrastructure of the lateral recess of the fourth ventricle in BALB/c mice in vivo. Methods: BALB/c mice were treated intragastrically by gavage with ST at a dosage of 3 000 μg/kg once. The experimental mice were killed on 1, 2, 4, 8 and 16 h after the oral administration. Ultrastructural changes of ependymal cells were observed with scanning electron microscopic method. Results: The results showed that 1 and 2 h after ST administration, the cilia of ependymal cells were significantly reduced. The cilia became twisted, adhered in tangle and some of them fallen down on the surface of ependymal cells. The changes were more obvious at 4 and 8 h after ST treatment. At the same time, a number of secretory vesicles and a few damaged superependymal cells were observed. Sixteen hours after ST treatment, the number and ultrastructural morphology of cilia on ependymal cells restored to the normal. Conclusion: Ultrastructural changes of the ependemal cells of the lateral recess of the fourth ventricle can be found after single oral administration of ST in mice, suggesting that ST may damage ependymal cells." @default.
- W2386622979 created "2016-06-24" @default.
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- W2386622979 date "2005-01-01" @default.
- W2386622979 modified "2023-09-25" @default.
- W2386622979 title "Effects of single oral administration of sterigmatocystin on lateral recess ultrastructure of fourth ventricle in mice" @default.
- W2386622979 hasPublicationYear "2005" @default.
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