Matches in SemOpenAlex for { <https://semopenalex.org/work/W2386631208> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2386631208 abstract "Thirteen adult guinea-pigs were divided into 3 groups:2 as normal controls;6 and 5 being treated with streptomycin sulphate 200 and 400mg per kilo body weight res- pectively for 21—60 days.The vestibular and auditory functions were tested.Their brains were prepared for Bielschowsky and Nissl sections.Microscopic examination re- vealed the following facts. Vascular disturbances prevail in the nervous system.The blood vessels are crumpled with concommittent perivascular edema.The adjacent nervous tissue shows ischemic softening and the nerve fibres become demyelinated. The intoxicated nerve cells are generally dehydrated and shrunken often with eccen- tricity of nuclei and chromophilic lumps.Gliosis and neurophagosis are common. The vestibular and cochlear systems of the eighth or stato-acoustic nerve exhibit intoxicative changes in the 2 groups of animals.On the peripheral as well as the central side,the degeneration of the vestibular structures supercedes that of the cochlear system. The site and nature of the intoxication are much alike in the light and heavy-dose groups,yet the latter shows a higher severity. The degenerative alterations appear simultaneously in the perpheral and central struc- tures.A question of primacy in intoxication—peripheral or central—is not existent. There is a chain of structures on the peripheral and central sides of the stato-acoustic system;their degeneration does not proceed along the conduction path,nor the degree of intoxication varies with their relative positions on the conduction scale.The peri- pheral and central units get intoxicated independently. Besides the stato-acoustic structures streptomycin afflicts other sensory(e.g.trige- minal) and motor systems,the viscero-motor in particular.Streptomycin intoxication is general in nature,yet some structures are especially sensitive to it. The relative vulnerability to streptomycin of the nervous structures is apparently conditioned by their chemical constitution. Streptomycin injuries higher brain parts which are mainly motor,especially viscero- motor.The diencephalic viscero-motor nuclei,the striate complex and the visceral cor- tex are excessively disintegrated.The extensive intoxicative manifestations have a neurological basis. The toxin of streptomycin affects the entire nervous system and hence the whole bodily mechanisms.Its medical application calls for a meticulous consideration with respect to the patient's sensitivity to the antibiotic,the size of the dose and the length of the therapeutic course." @default.
- W2386631208 created "2016-06-24" @default.
- W2386631208 creator A5065260156 @default.
- W2386631208 date "1963-01-01" @default.
- W2386631208 modified "2023-09-23" @default.
- W2386631208 title "NEUROTOXICITY OF STREPTOMYCIN (RSUM)" @default.
- W2386631208 hasPublicationYear "1963" @default.
- W2386631208 type Work @default.
- W2386631208 sameAs 2386631208 @default.
- W2386631208 citedByCount "0" @default.
- W2386631208 crossrefType "journal-article" @default.
- W2386631208 hasAuthorship W2386631208A5065260156 @default.
- W2386631208 hasConcept C105702510 @default.
- W2386631208 hasConcept C126322002 @default.
- W2386631208 hasConcept C142724271 @default.
- W2386631208 hasConcept C185592680 @default.
- W2386631208 hasConcept C190041318 @default.
- W2386631208 hasConcept C2775843808 @default.
- W2386631208 hasConcept C2777682930 @default.
- W2386631208 hasConcept C2779354088 @default.
- W2386631208 hasConcept C2779868778 @default.
- W2386631208 hasConcept C2780130748 @default.
- W2386631208 hasConcept C37753355 @default.
- W2386631208 hasConcept C501593827 @default.
- W2386631208 hasConcept C529278444 @default.
- W2386631208 hasConcept C548259974 @default.
- W2386631208 hasConcept C55493867 @default.
- W2386631208 hasConcept C71924100 @default.
- W2386631208 hasConcept C74864618 @default.
- W2386631208 hasConceptScore W2386631208C105702510 @default.
- W2386631208 hasConceptScore W2386631208C126322002 @default.
- W2386631208 hasConceptScore W2386631208C142724271 @default.
- W2386631208 hasConceptScore W2386631208C185592680 @default.
- W2386631208 hasConceptScore W2386631208C190041318 @default.
- W2386631208 hasConceptScore W2386631208C2775843808 @default.
- W2386631208 hasConceptScore W2386631208C2777682930 @default.
- W2386631208 hasConceptScore W2386631208C2779354088 @default.
- W2386631208 hasConceptScore W2386631208C2779868778 @default.
- W2386631208 hasConceptScore W2386631208C2780130748 @default.
- W2386631208 hasConceptScore W2386631208C37753355 @default.
- W2386631208 hasConceptScore W2386631208C501593827 @default.
- W2386631208 hasConceptScore W2386631208C529278444 @default.
- W2386631208 hasConceptScore W2386631208C548259974 @default.
- W2386631208 hasConceptScore W2386631208C55493867 @default.
- W2386631208 hasConceptScore W2386631208C71924100 @default.
- W2386631208 hasConceptScore W2386631208C74864618 @default.
- W2386631208 hasOpenAccess W2386631208 @default.
- W2386631208 hasRelatedWork W1964748198 @default.
- W2386631208 hasRelatedWork W1987326451 @default.
- W2386631208 hasRelatedWork W2042543295 @default.
- W2386631208 hasRelatedWork W2047698983 @default.
- W2386631208 hasRelatedWork W2048113042 @default.
- W2386631208 hasRelatedWork W206637130 @default.
- W2386631208 hasRelatedWork W2082683215 @default.
- W2386631208 hasRelatedWork W2087601770 @default.
- W2386631208 hasRelatedWork W2087996636 @default.
- W2386631208 hasRelatedWork W2091339519 @default.
- W2386631208 hasRelatedWork W2143366973 @default.
- W2386631208 hasRelatedWork W2330278124 @default.
- W2386631208 hasRelatedWork W2413177607 @default.
- W2386631208 hasRelatedWork W2414444183 @default.
- W2386631208 hasRelatedWork W2417662893 @default.
- W2386631208 hasRelatedWork W2904676311 @default.
- W2386631208 hasRelatedWork W76142550 @default.
- W2386631208 hasRelatedWork W3024476511 @default.
- W2386631208 isParatext "false" @default.
- W2386631208 isRetracted "false" @default.
- W2386631208 magId "2386631208" @default.
- W2386631208 workType "article" @default.