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- W2386652599 abstract "【Objective】 To study the immunoregulatory effect of Atorvastatin,a 3-hydroxy-3-methyl-glutaryl coenzyme A(HMG-CoA) reductase inhibitor,on Bleomycin-induced pulmonary fibrosis in rats and its possible mechanism.【Methods】 Pulmonary fibrosis was induced in Wistar rats by intratracheal instillation of Bleomycin(5 mg/kg).Subsequently,the rats received daily Atorvastatin(10 mg/kg) orally.Four to six rats in each group were sacrificed 7 and 28 days after intratracheal instillation.Histological changes in the lungs were evaluated by hematoxylin-eosin and masson stain and scored.Hydroxyproline contents in lung tissues were detected.The levels of IFN-γ and IL-4 in bronchoalveolar lavage fluid(BALF) were measured by ELISA.【Results】 Inflammatory cell infiltration and fibrotic scores were more prominent in the model group compared to the control group.Hydroxyproline contents in lung tissue were significantly increased 28 days after intratracheal Bleomycin instillation.Atorvastatin apparently attenuated the degree of pulmonary fibrosis.Further study showed that Atorvastatin significantly increased IFN-γ levels while decreasing IL-4 levels in lung BALF.【Conclusions】 Atorvastatin had an inhibitory effect on Bleomycin-induced pulmonary fibrosis.This effect may be associated with its regulation on Th1/Th2 balance in the lung." @default.
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- W2386652599 date "2011-01-01" @default.
- W2386652599 modified "2023-09-24" @default.
- W2386652599 title "Atorvastatin attenuates Bleomycin-induced pulmonary fibrosis in rats" @default.
- W2386652599 hasPublicationYear "2011" @default.
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