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- W2386670595 abstract "Objective:To investigate the efficiency of of the DNA nanoparticles wrapped with PEG modified chitosan by oral delivery.Method:Various dosage (10μg,50μg,100μg,respectively) of plasmid pCMVβ were enwrapped in the modified chitosan,and administrated by oral route to Kunming white mice.The alimentary canal was stained with X-Gal according to standard protocols to investigate the efficiency of DNA transfection.Result:The results showed that transfection efficiency of chitosan-DNA nanoparticles modified with PEG was apparently enhanced than that without modification.With the amount of delivered DNA increased,the expression of the DNA in alimentary canal increased accordingly.And the mice oral administrated with the 10μg of modified chitosan-DNA nanoparticles exhibited the same transfection efficiency as that with 100μg of unmodified chitosan-DNA.Conclusion:The PEG modified chitosan wraped DNA had high transfection efficiency.It might be a potential way for oral delivery of non-viral vector system in gene therapy." @default.
- W2386670595 created "2016-06-24" @default.
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- W2386670595 date "2010-01-01" @default.
- W2386670595 modified "2023-09-26" @default.
- W2386670595 title "Transfection Efficiency of the DNA Nanoparticles Wrapped with PEG Modified Chitosan" @default.
- W2386670595 hasPublicationYear "2010" @default.
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