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- W2386673487 abstract "Objective:To investigate the possible correlation of the transforming growth factor-beta receptor type 1 gene(TGFBR1) Int7G24A and *6A polymorphisms with the susceptibility to gastric cardia adenocarcinoma(GCA) in a population of Northern China.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and PCR analyses were used to detect the genotype of TGFBR1 Int7G24A(intron 7) and *6A(exon 1) single nucleotide polymorphisms(SNPs) in 468 GCA patients and 584 healthy controls.The expression levels of TGFBR1 protein in surgically resected tumor tissues and corresponding carcinoma adjacent normal tissues in 110 patients with GCA were detected by immunohistochemistry method,and the relationship between the expression of TGFBR1 protein and the genotype was analyzed.Results:The distributions of genotype and allelotype frequencies of TGFBR1 Int7G24A polymorphism in GCA patients were significantly different from those in the healthy controls(P0.05).The risk of GCA in patients with A allelotype was increased 1.34 folds as the patients with G allelotype [adjusting for age,gender and family history of upper gastrointestinal diseases,odds ratio(OR) =1.34,95% confidence interval(CI) =1.03-1.87].Compared with GG genotype,the AA genotype significantly elevated the risk of GCA(adjusted OR =2.17,95% CI =1.15-3.72).Compared with GG genotype,GA or AA genotype carriers had a higher risk of stage Ⅲ and Ⅳ GCA(adjusted OR=1.41,95% CI=1.05-1.98).The genotype and allelotype distributions of TGFBR1 *6A polymorphism in GCA patients were not significantly different from those in the healthy controls(P0.05).The positive-expression rate of TGFBR1 protein in GCA tissues(27.3%) was significantly lower than that in the adjacent normal tissues(100%)(P0.01).However,the TGFBR1 protein expression was not associated with the genotypes of TGFBR1 Int7G24A and *6A(P0.05).Conclusion:A allelotype of TGFBR1 Int7G24A may be one of the factors that affect the risk of developing GCA in Northern China." @default.
- W2386673487 created "2016-06-24" @default.
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- W2386673487 date "2011-01-01" @default.
- W2386673487 modified "2023-09-23" @default.
- W2386673487 title "Correlation of TGF-β receptor type 1 gene Int7G24A and *6A polymorphisms with the risk of gastric cardia adenocarcinoma" @default.
- W2386673487 hasPublicationYear "2011" @default.
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