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- W2386688953 abstract "Objective To explore the relationship between the Toll-like receptor 4(TLR-4)/nuclear factorκappa B(NF-κB)signaling pathway and high-fat diet induced insulin resistance in mice adipose tissues.Methods Eighty C57BL/6 mice were randomly divided into two groups fed with normal diet and high fat diet respectively,and then randomly divided into eight subgroups in12 weeks.The weight,fasting blood glucose and serum insulin levels were detected,and the adipose tissue was observed through tissue slice with Hematoxylin-Eosin(HE)staining.Immunohistochemistry was used to detect the expression of inflammation factors such as tumor necrosis factorαlpha(TNF-α)and interleukin 6(IL-6)so as to describe the formation and development of fat local inflammation.Finally,the Western blot method was adopted to detect proteins of TLR-4/NF-κB.Results High-fat feeding induced insulin resistance model successfully.IR was verified in model group,but not in normal conrol(NC)group.The levels of the weight and the blood glucose in model group were markedly increased compared with NC group(P0.05)and high-fat diet induced the expression of TLR-4mRNA and protein in adipose tissue.TLR-4/NF-κB signaling pathway activation increased gradually along with the days of high-fat diet,and reached a maximum level at the fifth day.The adipose tissue increased TNF-αand IL-6 expression in parallel,and the fat cells became bigger.Conclusion The high expression of TLR-4/NF-κB in adipose tissue and the increasing of serum insulin is consistent.The high-fat diet can activated fat cells TLR-4/NF-κB signaling pathways,and have the association with the insulin resistance." @default.
- W2386688953 created "2016-06-24" @default.
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- W2386688953 date "2014-01-01" @default.
- W2386688953 modified "2023-09-23" @default.
- W2386688953 title "Relationship between Adipose Tissue TLR-4/NF-κB Signaling Pathway and High-fat Diet Induced Insulin Resistance in Mice" @default.
- W2386688953 hasPublicationYear "2014" @default.
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