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- W2386691617 abstract "Objective: To investigate the effect of paeoniflorin(PF) on cognitive impairment and neuronal apoptosis in aging mice induced by D-galactose(D-gal) and NaNO2.Methods: D-gal and NaNO2 was injected(s.c.) to establish an aging mice model.Spatial memory was detected by Morris water maze(MWM) test.We examined the level of malondialdehyde(MDA) levels,total superoxide dismutase(T-SOD),and glutathione peroxidase(GSH-Px) activities in brain,and also observed neuronal death in hippocampus using HE-stained section,TUNEL positive nuclei,and caspase-3 positive cells in immunohistochemical stained sections.Results: D-gal and NaNO2 treated mice had significant deficits in cognitive function,by increasing cell karyopyknosis,apoptosis,and caspase-3 positive cells in the hippocampus.Administration of PF to D-gal and NaNO2-treated mice ameliorated cognitive impairment and neurodegeneration in the hippocampus,and decreased MDA level and increased T-SOD,and GSH-Px activities.The PF treated mice also had a decrease in caspase-3 positive cells in the hippocampus.Conclusion: Administration of PF into mice after chronic D-gal and NaNO2 exposure resulted in amelioration of cognitive impairment and neurodegeneration via inhibiting oxidative damage pathways." @default.
- W2386691617 created "2016-06-24" @default.
- W2386691617 creator A5036923059 @default.
- W2386691617 date "2009-01-01" @default.
- W2386691617 modified "2023-09-22" @default.
- W2386691617 title "Paeoniflorin ameliorates cognitive impairment and neurodegeneration in senescent mice induced by D-galactose and sodium nitrite" @default.
- W2386691617 hasPublicationYear "2009" @default.
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