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- W2386707181 abstract "Objective To explore the changes of MDM2 gene expression in SD rats' blood induced by chronic137Cs γ ray irradiation. Methods 120 SPF SD rats were randomly divided into 11 dose groups and 1 control group,with 10 rats in each group. 11 dose groups were respectively exposed to γ ray of137Cs with the chronic accumulated irradiation doses at0. 05,0. 10,0. 20,0. 40,0. 60,0. 80,1. 00,2. 00,3. 00,4. 00,5. 00 Gy,while control group was not exposed. The changes of MDM2 gene in peripheral blood were detected by real-time PCR. Results After irradiation,the expression of MDM2 gene in rats' peripheral blood up-regulated generally then decreased compared with that in the control group. Specifically,from 0. 10 Gy to 0. 20 Gy,the expression of MDM2 gene decreased with the increase of irradiation dose. Then,from 0. 20 Gy to 2. 00 Gy,the expression of MDM2 gene increased gradually compared with that of the control. At the dose range of 0. 20- 2. 00 Gy a linear regression equation(^y = 1. 918 9 x + 0. 386 0,determination coefficient = 0. 99,P 0. 01) was obtained using statistics regression analysis method. After 2. 00 Gy of exposure the expression of MDM2 gene decreased gradually. Conclusion137Cs γ ray chronic irradiation can induce the changes of MDM2 gene expression in peripheral blood of rats,and the gene expression level was first up-regulated then decreased,there was good dose-effect relationship in gene expression with the exposure of 0. 20- 2. 00 Gy of irradiation." @default.
- W2386707181 created "2016-06-24" @default.
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- W2386707181 date "2013-01-01" @default.
- W2386707181 modified "2023-09-28" @default.
- W2386707181 title "Study on expression changes of MDM2 gene in SD rats' blood after chronic ~(137)Csγ ray irradiation" @default.
- W2386707181 hasPublicationYear "2013" @default.
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