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- W2386730790 abstract "Aim: To investigate the changes of the plasma ANP and serum CK MB in patients with acute myocardial infarction and the relationship between the changes of the both and the heart dysfunction. Methods: Synchronized plasma ANP and serum CK MB were measured in 54 patients with acute myocardial infarction at 1, 6, 12, 18, 24, 48,and 72 hours after occurance. The patients were divided into three groups: Group Ia, the patients without thrombolytic therapy or without reperfusion through thrombolytic therapy;Group Ib, reperfusion;Group II, companied with heart dysfunction and without thrombolytic therapy. Results: The concentrations of ANP and CK MB increased, and the raising of ANP had two peaks. The first peak appeared within 1 hour after the occurance of symptoms then dropped swiptly. Within 12 hours, it expressed a negative correlation ( r = 0.62, P 0.01) compared with the increasing degree of CK MB. After 12 hours, the degree of ANP increased again and formed the second peak. After 48 hours, both the concentrations of ANP and CK MB decreased and formed a positive correlation( r =0.48, P 0.05). The concentrations of ANP and CK MB in Group Ia was not significant compared with Group Ib. And the concentrations of both in Group Ib were lower than those of Group Ⅱ any times ( P 0.001). Conclusions: The first raising level of ANP is mainly the releasing of secreting granules in atria due to heart dysfunction and is earlier than that of CK MB. The second raising level of ANP is mainly the synthesis and releasing of ANP in atrial and ventricular cells due to myocardial necrosis. Both the concentrations of ANP and CK MB may be used to judge the heart dysfunction and guide to drug choice. Thrombolytic therapy has no any effect on decreasing the concentration of ANP." @default.
- W2386730790 created "2016-06-24" @default.
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- W2386730790 date "2004-01-01" @default.
- W2386730790 modified "2023-09-23" @default.
- W2386730790 title "Measurement of the plasma ANP and serum CK-MB in patients with acute myocardial infarction" @default.
- W2386730790 hasPublicationYear "2004" @default.
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