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- W2386745405 abstract "Objective To investigate the influence of CO_2 pneumoperitoneum on intestinal mucosa permeability in rats with liver cirrhosis.Methods Fifty rats were randomly divided into following groups: control group(n=5),cirrhosis group(n=5) and pneumoperitoneum group(n=40);the pneumoperitoneum group was further divided into 8 mm Hg group(n=20) and 13 mm Hg group(n=20).Four time points were chosen,including 0.5,2,6,and 12 hours after the end of pneumoperitoneum.After rat models with cirrhosis were established successfully,the abdominal cavity was insufflated with CO_2 and maintained under the pressures of 8 mm Hg and 13 mm Hg respectively for two hours.The portal venous blood was collected and the levels of D-lactic acid and endotoxin were measured.Results The levels of endotoxin and D-lactic acid in cirrhosis group were much higher than those of control group(P0.05).The levels of serum endotoxin and D-lactic acid in pneumoperitoneum group were higher than those of cirrhosis group(P(0.05)) regardless of pressure and time point.The endotoxin level in 13 mm Hg group was higher than that of 8 mm Hg group on different time points(F=5.466,P0.05),but there was no difference in D-lactic acid level between both of them(F=0.415,P0.05).Conclusion The intestinal mucosa permeability is increased in rats with liver cirrhosis.It can be further increased under CO_2 pneumoperitoneum with certain pressure and time and in a pressure-dependent manner.The permeability can decrease after removal of pneumoperitoneum." @default.
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- W2386745405 date "2005-01-01" @default.
- W2386745405 modified "2023-09-22" @default.
- W2386745405 title "Experimental Study of Influence of CO_2 Pneumoperitoneum on Intestinal Mucosa Permeability in Rats with Liver Cirrhosis" @default.
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