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- W2386749802 abstract "OBJECTIVE:To investigate the effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on the expression of Survivin in human esophageal squamous cancer line Eca109 and human gastric cancer line SGC-7901 cells.METHODS:The expressions of Survivin in Eca109 and SGC-7901 cells were examined by immunocytochemical staining and Western blot analysis.The effect of YC-1 on apoptosis and cell cycle was detected by flow cytometry assay.The effect of YC-1 on proliferation was detected by MTT assay.RESULTS:YC-1 showed inhibitory expression effect of Survivin.Serial concentrations (5,10,20,30 and 40 μmol/L) of YC-1 were added to the media.The inhibitory rates of proliferation in Eca109 cells were (21.95±2.05)%,(30.69±2.59)%,(50.19±2.28)%,(61.17±2.09)% and (67.50±1.99)% respectively,and were (9.32±0.61)%,(17.86%±1.33)%,(36.95±2.01)%,(47.55±1.68)% and (56.01±1.12)% respectively in SGC-7901 cells(P0.05).The apoptosis rates for 10,20,30 μmol/L YC-1 were (14.1±0.81)%,(22.1±0.70)% and (24.6±1.01)% respectively in Eca109 cells,and were (15.9±0.75)%,(19.2±0.68)% and (25.4±0.95)% respectively in SGC-7901 cells(P0.05).Twenty μmol/L YC-1 induced the increase of S cycle in Eca109 and SGC-7901 cells.The S cycle proportions were (52.19±3.53)% and (54.61±4.12)% respectively in Eca109 and SGC-7901 cells,while were (21.45±0.91)% and (24.41±2.12)% respectively in the control groups(P0.05).CONCLUSION:YC-1 effectively suppresses the expression of Survivin,induces the apoptosis and inhibits the proliferation in Eca109 and SGC-7901 cell lines." @default.
- W2386749802 created "2016-06-24" @default.
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- W2386749802 date "2009-01-01" @default.
- W2386749802 modified "2023-09-25" @default.
- W2386749802 title "Effects of Suppression of Survivin by YC-1 on apoptosis and proliferation of Eca109 and SGC-7901 cell lines" @default.
- W2386749802 hasPublicationYear "2009" @default.
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