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- W2386750442 abstract "Objective: To investigate the effect of 8 weeks aerobic exercise on the left ventricular hypertrophy and the Rho GTPases in rat myocardium.Method: 20 Wistar rats were randomly assigned to either a sedentary or an aerobic exercise group.The treadmill exercise is adopted by the aerobic exercise group.The level of ventricular remodeling were measured using the left ventricular hypertrophy index(LVHI).The protein levels of RhoA,Rac1 and Cdc42 were measured using the Western Blot method.Furthermore,the mRNA levels of RhoA,Rac1 and Cdc42 were measured with Real Time PCR method.Result: 8 weeks exercise decreases the protein levels and mRNA levels of RhoA,Rac1 and Cdc42 but does not induce the ventricular remodeling.Conclusion: Rho GTPases protein expressions and gene transcriptions in myocardium are mediated by exercise,which may be an important molecular mechanism of adaptations of myocardium structure and function to physical activity." @default.
- W2386750442 created "2016-06-24" @default.
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- W2386750442 date "2012-01-01" @default.
- W2386750442 modified "2023-09-24" @default.
- W2386750442 title "The Effect of Exercise on the Rho GTPases in Rat Myocardium" @default.
- W2386750442 hasPublicationYear "2012" @default.
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