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- W2386754691 abstract "Objective:To study the relationship between the learning/memory ability and the expression changes of brain- derived neurotrophic factor(BDNF)mRNA and protein in hippocampus of epileptic rats kindled by Pentylenetetrazole(PTZ). Methods:Adult male Sprague-Dawley(SD)rats,weighing(200±20)g,were randomly divided into status epilepticus(SE) group,ControlⅠ,chronic epilepsy(CEP)group and ControlⅡ.Rats in SE group were initially administrated i.p.with 40 mg/kg PTZ,10 rain later with 20 mg/kg PTZ,and then with 10 mg/kg PTZ thereafter until the development of SE;rats in CEP group were administrated with 35 mg/kg PTZ for 3 times at an interval of 48 h,until the development of RacincⅣ-Ⅴepilepsy;and rats in ControlⅠand ControlⅡgroups were given normal saline in the same manners as SE group and CEP group,respectively.Alternative electro-stimulus Y-maze test was used to evaluate the learning/memory ability of rats;RT-PCR and immunohistochemistry method were used to determine the expression of BDNF mRNA and protein in rats' hippocampus. Results:On the first and second day after kindling,we found that the total errors of rats in SE group were obviously increased compared with those in ControlⅠ(P0.05);the total errors of CEP group on the first,thirtieth and thirty-first day were obviously increased compared with those in ControlⅡ(P0.05).Lower expression of BDNF mRNA and protein in hippocampus was found 1 day after kindling in SE and CEP group and 30 days after kindling in CEP group.Conclusion:Status epilepsy can induce short term deficiency of learning and memory in rats,while chronic epilepsy induces a longer deficiency. Learning and memory deficiency caused by epilepsy might be related to the decrease of BDNF mRNA and protein expression." @default.
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- W2386754691 date "2007-01-01" @default.
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- W2386754691 title "Expression changes of brain-derived neurotrophic factor in hippocampus of rats with post-epilepsy learning and memory deficiency" @default.
- W2386754691 hasPublicationYear "2007" @default.
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