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- W2386766579 abstract "Objective:To investigate the effects of rosiglitazone on the expression of extracellular matrix on rats with subtotal renal ablation,and explore its mechanism.Methods:Rats were randomly assigned to four groups with 8 animals in each group:sham-operated(SHAM) group,subtotal renal ablation(NX) group,NX treated with rosiglitazone(5 mg·kg-1·d-1)(XL group),NX treated with rosiglitazone(15 mg·kg-1·d-1)(DL group).The urinary protein,BUN and serum creatinine(Scr) were measured after 8 weeks.renal pathological changes were evaluated.The expression of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) were detected by way of immunohistochemistry.Renal mesangial collagen fibers were stained with Picric acid-Sirius red.The expression of FN were detected by way of RT-PCR.Results:(1)Compared with the NX group,24 hours urinary protein,BUN,serum creatinine(Scr) of Rosiglitazone treatment groups rats were substantially decreased,(P0.05).(2)Pathohistological study revealed that,compared with the NX group,there were less glomerular matris,collagen and fibronectin in Rosiglitazone treatment groups.Among the subtotal nephrectomy rats,DL group had the least renal changes in collagen and fibronectin dposition.There were less MMP-9 in DL group than those in NX group.There were more MMP-2 in DL group than those in NX group.(3)The levels of FN mRNA in all experimental groups rats were remarkably less than those in NX group.Conclusion:(1)Rosiglitazone can reduce 24 hours urinary protein,BUN,serum creatinine(Scr) and improve renal historical damage.(2)Rosiglitazone can decrease the level of FN mRNA and reduce renal extracellular matrix accumulation on rats with subtotal renal ablation and significantly prevents renal injury.(3)Rosiglitazone can inhibit MMP-9,increase MMP-2.Rosiglitazone significantly prevents renal injury following subtotal renal ablation." @default.
- W2386766579 created "2016-06-24" @default.
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- W2386766579 date "2008-01-01" @default.
- W2386766579 modified "2023-09-23" @default.
- W2386766579 title "Effects and Mechanism of Rosiglitazone on the Expression of Extracellular Matrix on Rat Remnant Kidney" @default.
- W2386766579 hasPublicationYear "2008" @default.
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